The 68-year-old is “self-isolating at home”, the minister, Faisal Sultan, tweeted.
Mr. Khan, a former captain of the national cricket team who became prime minister in August 2018, received his first vaccination two days ago.
Pakistan has recorded 13,799 deaths and 623,135 cases during the pandemic, according to Johns Hopkins University.
Vaccination helps develop immunity to the virus that causes Covid-19. Still, it usually takes a few weeks for protection to develop, and the person getting the jab remains vulnerable during that time.
The prime minister has been attending regular meetings, including at a security conference in the capital Islamabad attended by a large number of people, Reuters news agency notes.
He addressed that conference without wearing a mask and attended another gathering to inaugurate a housing project for poor people on Friday, the agency reports.
He received his first dose of the Chinese-produced Sinopharm vaccine on Thursday. The former cricketing superstar is generally in good health, and his adviser described him as remaining “hale and hearty.”
Vaccine hesitancy has been a significant concern in Pakistan. The prime minister’s decision to broadcast footage of himself receiving the jab was praised as an attempt to encourage others to do the same. It seems sure Mr. Khan had already been infected before the vaccination but fears the episode will boost vaccine skepticism.
Partial lockdown restrictions have recently been reintroduced in parts of the country following a rise in cases.